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EMD-31880
Cryo-EM structure of the non-acylated tirzepatide (LY3298176)-bound human GLP-1R-Gs complex
EMD-31880
Single-particle3.0 Å
Deposition: 31/08/2021Map released: 02/03/2022
Last modified: 16/03/2022
Sample Organism:
Homo sapiens,
Escherichia coli,
Rattus norvegicus,
Bos taurus
Sample: Cryo-EM structure of the human glucagon-like peptide-1 receptor in complex with non-acylated_tirzepatide and G protein
Fitted models: 7vbi
Deposition Authors: Zhao FH, Zhou QT, Cong ZT, Hang KN, Zou XY, Zhang C, Chen Y, Dai AT, Liang AY, Ming QQ, Wang M, Chen LN, Xu PY, Chang RL, Feng WB, Xia T, Zhang Y
,
Wu BL,
Yang DH,
Zhao LH,
Xu HE ,
Wang MW
Sample: Cryo-EM structure of the human glucagon-like peptide-1 receptor in complex with non-acylated_tirzepatide and G protein
Fitted models: 7vbi
Deposition Authors: Zhao FH, Zhou QT, Cong ZT, Hang KN, Zou XY, Zhang C, Chen Y, Dai AT, Liang AY, Ming QQ, Wang M, Chen LN, Xu PY, Chang RL, Feng WB, Xia T, Zhang Y
,
Wu BL,
Yang DH,
Zhao LH,
Xu HE ,
Wang MW
Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.
Zhao F,
Zhou Q,
Cong Z,
Hang K,
Zou X,
Zhang C,
Chen Y,
Dai A,
Liang A,
Ming Q,
Wang M,
Chen LN,
Xu P ,
Chang R,
Feng W,
Xia T,
Zhang Y ,
Wu B ,
Yang D ,
Zhao L ,
Xu HE ,
Wang MW
(2022) Nat Commun , 13 , 1057 - 1057
,
Chang R,
Feng W,
Xia T,
Zhang Y ,
Wu B ,
Yang D ,
Zhao L ,
Xu HE ,
Wang MW
(2022) Nat Commun , 13 , 1057 - 1057
Grant Support:
- National Natural Science Foundation of China (NSFC): 81872915 (China)
- National Natural Science Foundation of China (NSFC): 82073904 (China)
- National Natural Science Foundation of China (NSFC): 32071203 (China)
- National Natural Science Foundation of China (NSFC): 81922071 (China)
- National Natural Science Foundation of China (NSFC): 81773792 (China)
- National Natural Science Foundation of China (NSFC): 81973373 (China)
- National Natural Science Foundation of China (NSFC): 21704064 (China)