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EMD-31836

Single-particle
3.2 Å
EMD-31836
3D View Gallery
Deposition: 28/08/2021
Map released: 02/03/2022
Last modified: 02/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-31836
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7vab summary report (pdf.gz) Map and 7vab FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of the non-acylated tirzepatide (LY3298176)-bound human GIPR-Gs complex

EMD-31836

Single-particle
3.2 Å
EMD-31836
3D View Gallery
Deposition: 28/08/2021
Map released: 02/03/2022
Last modified: 02/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct, Rattus norvegicus, Bos taurus
Sample: Cryo-EM structure of the human glucose-dependent insulinotropic polypeptide receptor in complex with non-acylated_tirzepatide and G protein
Fitted models: 7vab

Deposition Authors: Zhao FH, Zhou QT
Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.
Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P , Chang R, Feng W, Xia T, Zhang Y , Wu B , Yang D , Zhao L , Xu HE , Wang MW
(2022) Nat Commun , 13 , 1057 - 1057
PUBMED: 35217653
DOI: doi:10.1038/s41467-022-28683-0
ISSN: 2041-1723