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EMD-31676
Cryo-EM structure of the GIPR/GLP-1R/GCGR triagonist peptide 20-bound human GCGR-Gs complex
EMD-31676
Single-particle3.5 Å
Deposition: 10/08/2021Map released: 02/03/2022
Last modified: 16/03/2022
Sample Organism:
Homo sapiens,
synthetic construct,
Rattus norvegicus,
Bos taurus
Sample: Cryo-EM structure of the GIPR/GLP-1R/GCGR triagonist peptide 20-bound human GCGR-Gs complex
Fitted models: 7v35
Deposition Authors: Zhao F, Zhou QT, Cong ZT, Hang KN, Zou XY, Zhang C, Chen Y, Dai AT, Liang AY, Ming QQ, Wang M, Chen LN, Xu PY, Chang RL, Feng WB, Xia T, Zhang Y
,
Wu BL,
Yang DH,
Zhao LH,
Xu HE ,
Wang MW
Sample: Cryo-EM structure of the GIPR/GLP-1R/GCGR triagonist peptide 20-bound human GCGR-Gs complex
Fitted models: 7v35
Deposition Authors: Zhao F, Zhou QT, Cong ZT, Hang KN, Zou XY, Zhang C, Chen Y, Dai AT, Liang AY, Ming QQ, Wang M, Chen LN, Xu PY, Chang RL, Feng WB, Xia T, Zhang Y
,
Wu BL,
Yang DH,
Zhao LH,
Xu HE ,
Wang MW
Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.
Zhao F,
Zhou Q,
Cong Z,
Hang K,
Zou X,
Zhang C,
Chen Y,
Dai A,
Liang A,
Ming Q,
Wang M,
Chen LN,
Xu P ,
Chang R,
Feng W,
Xia T,
Zhang Y ,
Wu B ,
Yang D ,
Zhao L ,
Xu HE ,
Wang MW
(2022) Nat Commun , 13 , 1057 - 1057
,
Chang R,
Feng W,
Xia T,
Zhang Y ,
Wu B ,
Yang D ,
Zhao L ,
Xu HE ,
Wang MW
(2022) Nat Commun , 13 , 1057 - 1057
Grant Support:
- National Natural Science Foundation of China (NSFC): 81872915 (China)
- National Natural Science Foundation of China (NSFC): 82073904 (China)
- National Natural Science Foundation of China (NSFC): 32071203 (China)
- National Natural Science Foundation of China (NSFC): 81922071 (China)
- National Natural Science Foundation of China (NSFC): 81773792 (China)
- National Natural Science Foundation of China (NSFC): 81973373 (China)
- National Natural Science Foundation of China (NSFC): 81922071 (Y.Z.), 81773792 (D.Y.), 81973373 (D.Y.) and 21704064 (Q.Z.); National Science and Technology Major (China)