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EMD-31341

Single-particle
2.98 Å
EMD-31341
3D View Gallery
Deposition: 24/05/2021
Map released: 29/09/2021
Last modified: 02/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-31341
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7evy summary report (pdf.gz) Map and 7evy FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of siponimod -bound Sphingosine-1-phosphate receptor 1 in complex with Gi protein

EMD-31341

Single-particle
2.98 Å
EMD-31341
3D View Gallery
Deposition: 24/05/2021
Map released: 29/09/2021
Last modified: 02/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: Sphingosine-1-phosphate receptor 1 complexed with Gi protein with bound siponimod
Fitted models: 7evy

Deposition Authors: Jia GW, Yuan Y
Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition.
Yuan Y, Jia G, Wu C , Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z , Shao Z
(2021) Cell Res , 31 , 1263 - 1274
PUBMED: 34526663
DOI: doi:10.1038/s41422-021-00566-x
ISSN: 1001-0602