EMD-30614

Single-particle
2.6 Å
EMD-30614
3D View Gallery
Deposition: 11/10/2020
Map released: 27/01/2021
Last modified: 02/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-30614

Archive Files (Depositor)

Primary 3D volume (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-7d8x summary report (pdf.gz) Map-7d8x FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

CryoEM structure of human gamma-secretase in complex with E2012 and L685458

EMD-30614

Single-particle
2.6 Å
EMD-30614
3D View Gallery
Deposition: 11/10/2020
Map released: 27/01/2021
Last modified: 02/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: human gamma-secretase
Fitted models: 7d8x

Deposition Authors: Yang G, Zhou R
Structural basis of gamma-secretase inhibition and modulation by small molecule drugs.
Yang G, Zhou R , Guo X, Yan C , Lei J, Shi Y
(2021) Cell , 184 , 521 - 533.e14
PUBMED: 33373587
DOI: doi:10.1016/j.cell.2020.11.049
ISSN: 1097-4172