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EMD-29980
Cryo-EM structure of serine 87 O-GlcNAc-modified alpha-synuclein fibrils
EMD-29980
Helical reconstruction4.8 Å
Deposition: 07/03/2023Map released: 08/11/2023
Last modified: 06/11/2024
Sample Organism:
Homo sapiens
Sample: alpha-synuclein fibrils
Fitted models: 8gf7
Deposition Authors: Balana JA, Nguyen AB, Saelices L
,
Pratt RM
Sample: alpha-synuclein fibrils
Fitted models: 8gf7
Deposition Authors: Balana JA, Nguyen AB, Saelices L
,
Pratt RM
O-GlcNAc forces an alpha-synuclein amyloid strain with notably diminished seeding and pathology.
Balana AT,
Mahul-Mellier AL,
Nguyen BA ,
Horvath M ,
Javed A,
Hard ER,
Jasiqi Y,
Singh P ,
Afrin S,
Pedretti R,
Singh V ,
Lee VM,
Luk KC,
Saelices L ,
Lashuel HA ,
Pratt MR
(2024) Nat Chem Biol , 20 , 646 - 655
,
Horvath M ,
Javed A,
Hard ER,
Jasiqi Y,
Singh P ,
Afrin S,
Pedretti R,
Singh V ,
Lee VM,
Luk KC,
Saelices L ,
Lashuel HA ,
Pratt MR
(2024) Nat Chem Biol , 20 , 646 - 655
Grant Support:
- Michael J. Fox Foundation: MJFF-008121 (United States)
- National Institutes of Health/Office of the Director: OD020103-01 (United States)
- National Institutes of Health/Office of the Director: OD021685-01A1 (United States)
- National Institutes of Health/National Institute on Aging (NIH/NIA): AG062418 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM114537 (United States)
- Department of Energy (DOE, United States): DE-AC02-76SF00515 (United States)
- Cancer Prevention and Research Institute of Texas (CPRIT): RP170644 (United States)