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EMD-29944
Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein
EMD-29944
Single-particle3.3 Å
Deposition: 03/03/2023Map released: 10/01/2024
Last modified: 06/11/2024
Sample Organism:
Homo sapiens,
Lama glama
Sample: Prostaglandin E Receptor EP4 Coupled to G Protein
Fitted models: 8gda
Deposition Authors: Shenming H, Mengyao X, Lei L, Jiangqian M, Sheng C, Jinpeng S
Sample: Prostaglandin E Receptor EP4 Coupled to G Protein
Fitted models: 8gda
Deposition Authors: Shenming H, Mengyao X, Lei L, Jiangqian M, Sheng C, Jinpeng S
Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths.
Huang SM,
Xiong MY 
,
Liu L ,
Mu J,
Wang MW ,
Jia YL ,
Cai K,
Tie L ,
Zhang C ,
Cao S,
Wen X,
Wang JL,
Guo SC,
Li Y,
Qu CX ,
He QT ,
Cai BY,
Xue C ,
Gan S ,
Xie Y,
Cong X,
Yang Z ,
Kong W,
Li S,
Li Z,
Xiao P ,
Yang F ,
Yu X,
Guan YF,
Zhang X ,
Liu Z ,
Yang BX,
Du Y ,
Sun JP
(2023) PNAS , 120 , e2216329120 - e2216329120
,
Liu L ,
Mu J,
Wang MW ,
Jia YL ,
Cai K,
Tie L ,
Zhang C ,
Cao S,
Wen X,
Wang JL,
Guo SC,
Li Y,
Qu CX ,
He QT ,
Cai BY,
Xue C ,
Gan S ,
Xie Y,
Cong X,
Yang Z ,
Kong W,
Li S,
Li Z,
Xiao P ,
Yang F ,
Yu X,
Guan YF,
Zhang X ,
Liu Z ,
Yang BX,
Du Y ,
Sun JP
(2023) PNAS , 120 , e2216329120 - e2216329120
Grant Support: