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EMD-29935
Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein
EMD-29935
Single-particle3.5 Å
Deposition: 02/03/2023Map released: 03/01/2024
Last modified: 30/10/2024
Sample Organism:
Homo sapiens
Sample: Cryo-EM Structure of Prostaglandin E Receptor EP4 Coupled to G Protein
Fitted models: 8gcm
Deposition Authors: Huang SM, Xiong MY
,
Liu L ,
Mu J,
Sheng C,
Sun J
Sample: Cryo-EM Structure of Prostaglandin E Receptor EP4 Coupled to G Protein
Fitted models: 8gcm
Deposition Authors: Huang SM, Xiong MY
,
Liu L ,
Mu J,
Sheng C,
Sun J
Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths.
Huang SM,
Xiong MY ,
Liu L ,
Mu J,
Wang MW ,
Jia YL ,
Cai K,
Tie L ,
Zhang C ,
Cao S,
Wen X,
Wang JL,
Guo SC,
Li Y,
Qu CX ,
He QT ,
Cai BY,
Xue C ,
Gan S ,
Xie Y,
Cong X,
Yang Z ,
Kong W,
Li S,
Li Z,
Xiao P ,
Yang F ,
Yu X,
Guan YF,
Zhang X ,
Liu Z ,
Yang BX,
Du Y ,
Sun JP
(2023) PNAS , 120 , e2216329120 - e2216329120
,
Liu L ,
Mu J,
Wang MW ,
Jia YL ,
Cai K,
Tie L ,
Zhang C ,
Cao S,
Wen X,
Wang JL,
Guo SC,
Li Y,
Qu CX ,
He QT ,
Cai BY,
Xue C ,
Gan S ,
Xie Y,
Cong X,
Yang Z ,
Kong W,
Li S,
Li Z,
Xiao P ,
Yang F ,
Yu X,
Guan YF,
Zhang X ,
Liu Z ,
Yang BX,
Du Y ,
Sun JP
(2023) PNAS , 120 , e2216329120 - e2216329120
Grant Support: