EMD-29714

Single-particle
2.2 Å
EMD-29714
3D View Gallery
Deposition: 08/02/2023
Map released: 08/03/2023
Last modified: 08/03/2023
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links

EMD-29714
Download
3D volume (map.gz) Experimental metadata (xml)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8g46 summary report (pdf.gz) Map and 8g46 FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of DDB1deltaB-DDA1-DCAF16-BRD4(BD2)-MMH2

EMD-29714

Single-particle
2.2 Å
EMD-29714
3D View Gallery
Deposition: 08/02/2023
Map released: 08/03/2023
Last modified: 08/03/2023
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Sample Organism: Homo sapiens
Sample: Ternary complex of cullin ring E3 ubiquitin ligase substrate receptor arm (DDB1deltaB-DDA1-DCAF16) in compound-induced complex with bromodomain 2 of BRD4
Fitted models: 8g46

Deposition Authors: Ma MW , Hunkeler M , Jin CY, Fischer ES
Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders.
Li YD , Ma MW , Hassan MM , Hunkeler M , Teng M , Puvar K , Lumpkin R, Sandoval B , Jin CY, Ficarro SB, Wang MY , Xu S, Groendyke BJ , Sigua LH , Tavares I , Zou C, Tsai JM , Park PMC , Yoon H , Majewski FC, Marto JA , Qi J , Nowak RP , Donovan KA , Slabicki M , Gray NS , Fischer ES , Ebert BL
(2023) bioRxiv
PUBMED: 36824856
DOI: doi:10.1101/2023.02.14.528208
ISSN: 2692-8205