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EMD-29644
Structure of signaling thrombopoietin-MPL receptor complex
EMD-29644
Single-particle3.4 Å
Deposition: 31/01/2023Map released: 30/08/2023
Last modified: 06/11/2024
Sample Organism:
Homo sapiens
Sample: Thrombopoietin signaling complex with two thrombopoietin receptor chains
Fitted models: 8g04
Deposition Authors: Tsutsumi N
,
Jude KM,
Gati C,
Garcia KC
Sample: Thrombopoietin signaling complex with two thrombopoietin receptor chains
Fitted models: 8g04
Deposition Authors: Tsutsumi N
,
Jude KM,
Gati C,
Garcia KC
Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis.
Tsutsumi N ,
Masoumi Z ,
James SC,
Tucker JA,
Winkelmann H ,
Grey W ,
Picton LK,
Moss L ,
Wilson SC ,
Caveney NA,
Jude KM,
Gati C,
Piehler J,
Hitchcock IS,
Garcia KC
(2023) Cell , 186 , 4189 - 4203.e22
,
Masoumi Z ,
James SC,
Tucker JA,
Winkelmann H ,
Grey W ,
Picton LK,
Moss L ,
Wilson SC ,
Caveney NA,
Jude KM,
Gati C,
Piehler J,
Hitchcock IS,
Garcia KC
(2023) Cell , 186 , 4189 - 4203.e22
Grant Support:
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): R37AI051321 (United States)
- Howard Hughes Medical Institute (HHMI): (United States)
- Ludwig Institute for Cancer Research (LICR): (United States)