EMD-29482

Single-particle
2.1 Å
EMD-29482
3D View Gallery
Deposition: 18/01/2023
Map released: 19/04/2023
Last modified: 06/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-29482

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8fuz summary report (pdf.gz) Map-8fuz FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Human IMPDH2 mutant - L245P, treated with GTP, ATP, IMP, and NAD+; filament assembly interface reconstruction

EMD-29482

Single-particle
2.1 Å
EMD-29482
3D View Gallery
Deposition: 18/01/2023
Map released: 19/04/2023
Last modified: 06/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Filament of Inosine-5'-monophosphate dehydrogenase 2 - L245P mutant, bound to GTP, ATP, IMP, and NAD+
Fitted models: 8fuz

Deposition Authors: O'Neill AG , Kollman JM
Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation.
O'Neill AG , Burrell AL, Zech M, Elpeleg O, Harel T, Edvardson S, Mor-Shaked H, Rippert AL , Nomakuchi T , Izumi K, Kollman JM
(2023) J Biol Chem , 299 , 105012 - 105012
PUBMED: 37414152
DOI: doi:10.1016/j.jbc.2023.105012
ISSN: 1083-351X
ASTM: JBCHA3