EMD-29321
Structure of E138K/G140S/Q148H HIV-1 intasome with Dolutegravir bound
EMD-29321
Single-particle2.2 Å
Deposition: 28/12/2022Map released: 09/08/2023
Last modified: 19/06/2024
Sample Organism:
Human immunodeficiency virus 1
Sample: E138K/G140S/Q148H HIV-1 intasome bound to dolutegravir
Fitted models: 8fnp
Deposition Authors: Shan ZL, Passos DO
,
Strutzenberg TS ,
Li M ,
Lyumkis D
Sample: E138K/G140S/Q148H HIV-1 intasome bound to dolutegravir
Fitted models: 8fnp
Deposition Authors: Shan ZL, Passos DO
,
Strutzenberg TS ,
Li M ,
Lyumkis D
Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants.
Li M ,
Oliveira Passos D,
Shan Z ,
Smith SJ ,
Sun Q ,
Biswas A ,
Choudhuri I ,
Strutzenberg TS ,
Haldane A ,
Deng N ,
Li Z,
Zhao XZ ,
Briganti L ,
Kvaratskhelia M ,
Burke Jr TR ,
Levy RM ,
Hughes SH ,
Craigie R ,
Lyumkis D
(2023) Sci Adv , 9 , eadg5953 - eadg5953
,
Oliveira Passos D,
Shan Z ,
Smith SJ ,
Sun Q ,
Biswas A ,
Choudhuri I ,
Strutzenberg TS ,
Haldane A ,
Deng N ,
Li Z,
Zhao XZ ,
Briganti L ,
Kvaratskhelia M ,
Burke Jr TR ,
Levy RM ,
Hughes SH ,
Craigie R ,
Lyumkis D
(2023) Sci Adv , 9 , eadg5953 - eadg5953
Grant Support:
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): U01 AI136680 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): R01 AI146017 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): U54 AI170855 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R35 GM132090 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM148049 (United States)