EMD-29044

Single-particle
7.5 Å
EMD-29044
3D View Gallery
Deposition: 08/12/2022
Map released: 22/02/2023
Last modified: 13/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-29044
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8ffj summary report (pdf.gz) Map and 8ffj FULL report (pdf.gz)
EMICSS annotations (xml)

Structure of Zanidatamab bound to HER2

EMD-29044

Single-particle
7.5 Å
EMD-29044
3D View Gallery
Deposition: 08/12/2022
Map released: 22/02/2023
Last modified: 13/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Complex of Zanidatamab and HER2
Fitted models: 8ffj

Deposition Authors: Worrall LJ, Atkinson CE, Sanches M , Dixit S, Strynadka NCJ
An anti-HER2 biparatopic antibody that induces unique HER2 clustering and complement-dependent cytotoxicity.
Weisser NE , Sanches M , Escobar-Cabrera E, O'Toole J, Whalen E, Chan PWY, Wickman G, Abraham L, Choi K , Harbourne B, Samiotakis A, Rojas AH, Volkers G , Wong J , Atkinson CE, Baardsnes J, Worrall LJ, Browman D, Smith EE, Baichoo P, Cheng CW, Guedia J, Kang S, Mukhopadhyay A, Newhook L, Ohrn A, Raghunatha P , Zago-Schmitt M, Schrag JD, Smith J, Zwierzchowski P , Scurll JM, Fung V, Black S, Strynadka NCJ , Gold MR , Presta LG, Ng G, Dixit S
(2023) Nat Commun , 14 , 1394 - 1394
PUBMED: 36914633
DOI: doi:10.1038/s41467-023-37029-3
ISSN: 2041-1723
Grant Support: