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EMD-29044
Structure of Zanidatamab bound to HER2
EMD-29044
Single-particle7.5 Å
Deposition: 08/12/2022Map released: 22/02/2023
Last modified: 13/11/2024
Sample Organism:
Homo sapiens
Sample: Complex of Zanidatamab and HER2
Fitted models: 8ffj
Deposition Authors: Worrall LJ, Atkinson CE, Sanches M
,
Dixit S,
Strynadka NCJ
Sample: Complex of Zanidatamab and HER2
Fitted models: 8ffj
Deposition Authors: Worrall LJ, Atkinson CE, Sanches M
,
Dixit S,
Strynadka NCJ
An anti-HER2 biparatopic antibody that induces unique HER2 clustering and complement-dependent cytotoxicity.
Weisser NE ,
Sanches M ,
Escobar-Cabrera E,
O'Toole J,
Whalen E,
Chan PWY,
Wickman G,
Abraham L,
Choi K ,
Harbourne B,
Samiotakis A,
Rojas AH,
Volkers G ,
Wong J ,
Atkinson CE,
Baardsnes J,
Worrall LJ,
Browman D,
Smith EE,
Baichoo P,
Cheng CW,
Guedia J,
Kang S,
Mukhopadhyay A,
Newhook L,
Ohrn A,
Raghunatha P ,
Zago-Schmitt M,
Schrag JD,
Smith J,
Zwierzchowski P ,
Scurll JM,
Fung V,
Black S,
Strynadka NCJ ,
Gold MR ,
Presta LG,
Ng G,
Dixit S
(2023) Nat Commun , 14 , 1394 - 1394
,
Sanches M ,
Escobar-Cabrera E,
O'Toole J,
Whalen E,
Chan PWY,
Wickman G,
Abraham L,
Choi K ,
Harbourne B,
Samiotakis A,
Rojas AH,
Volkers G ,
Wong J ,
Atkinson CE,
Baardsnes J,
Worrall LJ,
Browman D,
Smith EE,
Baichoo P,
Cheng CW,
Guedia J,
Kang S,
Mukhopadhyay A,
Newhook L,
Ohrn A,
Raghunatha P ,
Zago-Schmitt M,
Schrag JD,
Smith J,
Zwierzchowski P ,
Scurll JM,
Fung V,
Black S,
Strynadka NCJ ,
Gold MR ,
Presta LG,
Ng G,
Dixit S
(2023) Nat Commun , 14 , 1394 - 1394
Grant Support:
- Not funded: (Canada)