EMD-28778

Single-particle
2.9 Å
EMD-28778
3D View Gallery
Deposition: 03/11/2022
Map released: 12/04/2023
Last modified: 12/04/2023
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-28778

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8f0r summary report (pdf.gz) Map-8f0r FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the arylsulfonamide inhibitor GNE-3565

EMD-28778

Single-particle
2.9 Å
EMD-28778
3D View Gallery
Deposition: 03/11/2022
Map released: 12/04/2023
Last modified: 12/04/2023
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: VSD4-NaV1.7-NaVPas channel chimera bound to the arylsulfonamide inhibitor GNE-3565
Fitted models: 8f0r

Deposition Authors: Kschonsak M , Jao CC, Arthur CP, Rohou AL, Bergeron P, Ortwine D, McKerall SJ, Hackos DH, Deng L, Chen J, Sutherlin D, Dragovich PS, Volgraf M, Wright MR, Payandeh J , Ciferri C , Tellis JC
Cryo-EM reveals an unprecedented binding site for Na V 1.7 inhibitors enabling rational design of potent hybrid inhibitors.
Kschonsak M , Jao CC, Arthur CP, Rohou AL, Bergeron P, Ortwine DF, McKerrall SJ, Hackos DH, Deng L, Chen J, Li T, Dragovich PS, Volgraf M, Wright MR, Payandeh J , Ciferri C , Tellis JC
(2023) eLife , 12
PUBMED: 36975198
DOI: doi:10.7554/eLife.84151
ISSN: 2050-084X
Grant Support: