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EMD-28777
Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the acylsulfonamide inhibitor GDC-0310
EMD-28777
Single-particle2.5 Å
Deposition: 03/11/2022Map released: 12/04/2023
Last modified: 12/04/2023
Sample Organism:
Homo sapiens
Sample: Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the acylsulfonamide inhibitor GDC-0310
Fitted models: 8f0q
Deposition Authors: Kschonsak M
,
Jao CC,
Arthur CP,
Rohou AL,
Bergeron P,
Ortwine D,
McKerall SJ,
Hackos DH,
Deng L,
Chen J,
Sutherlin D,
Dragovich PS,
Volgraf M,
Wright MR,
Payandeh J ,
Ciferri C ,
Tellis JC
Sample: Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the acylsulfonamide inhibitor GDC-0310
Fitted models: 8f0q
Deposition Authors: Kschonsak M
,
Jao CC,
Arthur CP,
Rohou AL,
Bergeron P,
Ortwine D,
McKerall SJ,
Hackos DH,
Deng L,
Chen J,
Sutherlin D,
Dragovich PS,
Volgraf M,
Wright MR,
Payandeh J ,
Ciferri C ,
Tellis JC
Cryo-EM reveals an unprecedented binding site for Na V 1.7 inhibitors enabling rational design of potent hybrid inhibitors.
Kschonsak M ,
Jao CC,
Arthur CP,
Rohou AL,
Bergeron P,
Ortwine DF,
McKerrall SJ,
Hackos DH,
Deng L,
Chen J,
Li T,
Dragovich PS,
Volgraf M,
Wright MR,
Payandeh J ,
Ciferri C ,
Tellis JC
(2023) eLife , 12
,
Jao CC,
Arthur CP,
Rohou AL,
Bergeron P,
Ortwine DF,
McKerrall SJ,
Hackos DH,
Deng L,
Chen J,
Li T,
Dragovich PS,
Volgraf M,
Wright MR,
Payandeh J ,
Ciferri C ,
Tellis JC
(2023) eLife , 12