EMD-28596
CryoEM Structure of NLRP3 NACHT domain in complex with G2394
EMD-28596
Single-particle3.5 Å
Deposition: 17/10/2022Map released: 02/11/2022
Last modified: 19/06/2024
Sample Organism:
Homo sapiens
Sample: NLRP3 NACHT domain
Fitted models: 8etr
Deposition Authors: Murray JM, Johnson MC
Sample: NLRP3 NACHT domain
Fitted models: 8etr
Deposition Authors: Murray JM, Johnson MC
Overcoming Preclinical Safety Obstacles to Discover ( S )- N -((1,2,3,5,6,7-Hexahydro- s -indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5 H -pyrazolo[5,1- b ][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor.
McBride C,
Trzoss L,
Povero D,
Lazic M,
Ambrus-Aikelin G,
Santini A,
Pranadinata R,
Bain G ,
Stansfield R,
Stafford JA,
Veal J,
Takahashi R,
Ly J,
Chen S,
Liu L,
Nespi M,
Blake R,
Katewa A,
Kleinheinz T,
Sujatha-Bhaskar S,
Ramamoorthi N,
Sims J,
McKenzie B,
Chen M,
Ultsch M,
Johnson M,
Murray J ,
Ciferri C,
Staben ST ,
Townsend MJ,
Stivala CE
(2022) J Med Chem , 65 , 14721 - 14739
,
Stansfield R,
Stafford JA,
Veal J,
Takahashi R,
Ly J,
Chen S,
Liu L,
Nespi M,
Blake R,
Katewa A,
Kleinheinz T,
Sujatha-Bhaskar S,
Ramamoorthi N,
Sims J,
McKenzie B,
Chen M,
Ultsch M,
Johnson M,
Murray J ,
Ciferri C,
Staben ST ,
Townsend MJ,
Stivala CE
(2022) J Med Chem , 65 , 14721 - 14739
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