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EMD-28551

Single-particle
2.86 Å
EMD-28551
3D View Gallery
Deposition: 11/10/2022
Map released: 28/12/2022
Last modified: 19/06/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-28551
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8era summary report (pdf.gz) Map and 8era FULL report (pdf.gz)
EMICSS annotations (xml)

RMC-5552 in complex with mTORC1 and FKBP12

EMD-28551

Single-particle
2.86 Å
EMD-28551
3D View Gallery
Deposition: 11/10/2022
Map released: 28/12/2022
Last modified: 19/06/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: RMC-5552-mTORC1-FKBP12
Fitted models: 8era

Deposition Authors: Tomlinson ACA , Yano JK
Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors.
Burnett GL , Yang YC , Aggen JB , Pitzen J, Gliedt MK, Semko CM, Marquez A , Evans JW, Wang G, Won WS, Tomlinson ACA , Kiss G, Tzitzilonis C, Thottumkara AP, Cregg J, Mellem KT, Choi JS, Lee JC, Zhao Y, Lee BJ, Meyerowitz JG, Knox JE, Jiang J, Wang Z, Wildes D, Wang Z, Singh M , Smith JAM, Gill AL
(2023) J Med Chem , 66 , 149 - 169
PUBMED: 36533617
DOI: doi:10.1021/acs.jmedchem.2c01658
ISSN: 0022-2623
ASTM: JMCMAR
Grant Support: