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EMD-28378

Single-particle
3.53 Å
EMD-28378
3D View Gallery
Deposition: 03/10/2022
Map released: 30/08/2023
Last modified: 30/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-28378
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8eok summary report (pdf.gz) Map and 8eok FULL report (pdf.gz)
EMICSS annotations (xml)

Structure of the C3bB proconvertase in complex with lufaxin and factor Xa

EMD-28378

Single-particle
3.53 Å
EMD-28378
3D View Gallery
Deposition: 03/10/2022
Map released: 30/08/2023
Last modified: 30/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Lutzomyia longipalpis
Sample: The C3 proconvertase from the alternative pathway of complement in complex with lufaxin, a complement/coagulation inhibitor and coagulation factor Xa
Fitted models: 8eok

Deposition Authors: Andersen JF , Lei H
A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism.
Andersen JF , Lei H, Strayer EC , Kanai T, Pham V, Pan XZ, Alvarenga PH , Gerber GF , Asojo OA , Francischetti IMB, Brodsky RA , Valenzuela JG , Ribeiro JMC
(2023) Blood , 141 , 3109 - 3121
PUBMED: 36947859
DOI: doi:10.1182/blood.2022019359
ISSN: 1528-0020