EMD-28228
SARS-CoV-2 spike glycoprotein in complex with the ICO-hu23 neutralizing antibody Fab fragment
EMD-28228
Single-particle3.6 Å
Deposition: 24/09/2022Map released: 19/07/2023
Last modified: 06/11/2024
Sample Organism:
Homo sapiens,
Severe acute respiratory syndrome coronavirus 2
Sample: SARS-CoV-2 spike glycoprotein in complex with the ICO-hu23 antibody Fab fragment
Fitted models: 8elj
Deposition Authors: Yee AW, Morizumi T, Kim K, Kuo A, Ernst OP
Sample: SARS-CoV-2 spike glycoprotein in complex with the ICO-hu23 antibody Fab fragment
Fitted models: 8elj
Deposition Authors: Yee AW, Morizumi T, Kim K, Kuo A, Ernst OP
Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in non-human primates.
Hermet P 
,
Delache B,
Herate C,
Wolf E,
Kivi G,
Juronen E,
Mumm K,
Zusinaite E,
Kainov D,
Sankovski E,
Virumae K,
Planken A,
Merits A,
Besaw JE,
Yee AW,
Morizumi T,
Kim K,
Kuo A,
Berriche A,
Dereuddre-Bosquet N,
Sconosciuti Q,
Naninck T,
Relouzat F,
Cavarelli M,
Ustav M,
Wilson D,
Ernst OP,
Mannik A,
LeGrand R,
Ustav Jr M
(2023) PLoS Pathog , 19 , e1011532 - e1011532
,
Delache B,
Herate C,
Wolf E,
Kivi G,
Juronen E,
Mumm K,
Zusinaite E,
Kainov D,
Sankovski E,
Virumae K,
Planken A,
Merits A,
Besaw JE,
Yee AW,
Morizumi T,
Kim K,
Kuo A,
Berriche A,
Dereuddre-Bosquet N,
Sconosciuti Q,
Naninck T,
Relouzat F,
Cavarelli M,
Ustav M,
Wilson D,
Ernst OP,
Mannik A,
LeGrand R,
Ustav Jr M
(2023) PLoS Pathog , 19 , e1011532 - e1011532
Grant Support:
- Canada Excellence Research Chair Award: (Canada)