EMD-28161

Single-particle
3.0 Å
EMD-28161
3D View Gallery
Deposition: 15/09/2022
Map released: 19/10/2022
Last modified: 28/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-28161

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8eiq summary report (pdf.gz) Map-8eiq FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) with Trikafta [elexacaftor (VX-445), tezacaftor (VX-661), ivacaftor (VX-770)] and ATP/Mg

EMD-28161

Single-particle
3.0 Å
EMD-28161
3D View Gallery
Deposition: 15/09/2022
Map released: 19/10/2022
Last modified: 28/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) with Trikafta [elexacaftor (VX-445), tezacaftor (VX-661), ivacaftor (VX-770)] and ATP/Mg
Fitted models: 8eiq

Deposition Authors: Fiedorczuk K , Chen J
Molecular structures reveal synergistic rescue of Delta 508 CFTR by Trikafta modulators.
Fiedorczuk K , Chen J
(2022) Science , 378 , 284 - 290
PUBMED: 36264792
DOI: doi:10.1126/science.ade2216
ISSN: 1095-9203
ASTM: SCIEAS
Grant Support: