Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-27811

Single-particle
3.6 Å
EMD-27811
3D View Gallery
Deposition: 08/08/2022
Map released: 30/08/2023
Last modified: 04/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-27811
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8e00 summary report (pdf.gz) Map and 8e00 FULL report (pdf.gz)
EMICSS annotations (xml)

Symmetry expansion of yeast cytoplasmic dynein-1 bound to Lis1 in the chi conformation.

EMD-27811

Single-particle
3.6 Å
EMD-27811
3D View Gallery
Deposition: 08/08/2022
Map released: 30/08/2023
Last modified: 04/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Saccharomyces cerevisiae
Sample: cytoplasmic dynein(E2448Q) bound to Lis1 in chi conformation
Fitted models: 8e00

Deposition Authors: Reimer JM, Lahiri I, Leschziner AE
Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge.
Karasmanis EP , Reimer JM, Kendrick AA , Nguyen KHV, Rodriguez JA, Truong JB , Lahiri I, Reck-Peterson SL , Leschziner AE
(2023) Nat Struct Mol Biol , 30 , 1357 - 1364
PUBMED: 37620585
DOI: doi:10.1038/s41594-023-01069-6
ISSN: 1545-9985