EMD-27730
SARS-CoV-2 Wuhan-hu-1-Spike-RBD bound to linker variant of affinity matured ACE2 mimetic CVD432
EMD-27730
Single-particle3.4 Å
Deposition: 27/07/2022Map released: 31/08/2022
Last modified: 06/11/2024
Sample Organism:
Severe acute respiratory syndrome coronavirus 2,
Homo sapiens
Sample: SARS-CoV-2 Wuhan-hu-1-Spike bound to linker variant of affinity matured ACE2 mimetic CVD432
Fitted models: 8dv1
Deposition Authors: QCRG Structural Biology Consortium, Remesh SG, Merz GE
,
Brilot AF,
Chio U,
Verba KA
Sample: SARS-CoV-2 Wuhan-hu-1-Spike bound to linker variant of affinity matured ACE2 mimetic CVD432
Fitted models: 8dv1
Deposition Authors: QCRG Structural Biology Consortium, Remesh SG, Merz GE
,
Brilot AF,
Chio U,
Verba KA
Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps.
Remesh SG,
Merz GE
,
Brilot AF,
Chio US,
Rizo AN,
Pospiech Jr TH,
Lui I,
Laurie MT,
Glasgow J,
Le CQ,
Zhang Y,
Diwanji D,
Hernandez E,
Lopez J
,
Mehmood H
,
Pawar KI,
Pourmal S,
Smith AM,
Zhou F,
DeRisi J,
Kortemme T,
Rosenberg OS,
Glasgow A,
Leung KK,
Wells JA,
Verba KA
(2023) Structure , 31 , 253
,
Brilot AF,
Chio US,
Rizo AN,
Pospiech Jr TH,
Lui I,
Laurie MT,
Glasgow J,
Le CQ,
Zhang Y,
Diwanji D,
Hernandez E,
Lopez J
,
Mehmood H
,
Pawar KI,
Pourmal S,
Smith AM,
Zhou F,
DeRisi J,
Kortemme T,
Rosenberg OS,
Glasgow A,
Leung KK,
Wells JA,
Verba KA
(2023) Structure , 31 , 253
Grant Support:
- Department of Defense (DOD, United States): HR0011-19-2-0020 (United States)
- Chan Zuckerberg Initiative: (United States)
- Mercatus Center: Emergent Ventures #2154 (United States)
