EMD-27692
LM18/Nb136 bispecific tetra-nanobody immunoglobulin in complex with SARS-CoV-2-6P-Mut7 S protein (focused refinement)
EMD-27692
Single-particle3.34 Å
Deposition: 25/07/2022Map released: 14/06/2023
Last modified: 20/11/2024
Sample Organism:
Severe acute respiratory syndrome coronavirus 2,
synthetic construct
Sample: LM18/Nb136 bispecific tetra-nanobody immunoglobulin in complex with SARS-CoV-2-6P-Mut7 S protein
Fitted models: 8dt8
Deposition Authors: Ozorowski G
,
Turner HL,
Ward AB
Sample: LM18/Nb136 bispecific tetra-nanobody immunoglobulin in complex with SARS-CoV-2-6P-Mut7 S protein
Fitted models: 8dt8
Deposition Authors: Ozorowski G
,
Turner HL,
Ward AB
Fully synthetic platform to rapidly generate tetravalent bispecific nanobody-based immunoglobulins.
Misson Mindrebo L,
Liu H ,
Ozorowski G ,
Tran Q ,
Woehl J ,
Khalek I,
Smith JM ,
Barman S,
Zhao F ,
Keating C,
Limbo O ,
Verma M ,
Liu J ,
Stanfield RL ,
Zhu X ,
Turner HL,
Sok D,
Huang PS ,
Burton DR ,
Ward AB ,
Wilson IA ,
Jardine JG
(2023) PNAS , 120 , e2216612120 - e2216612120
,
Ozorowski G ,
Tran Q ,
Woehl J ,
Khalek I,
Smith JM ,
Barman S,
Zhao F ,
Keating C,
Limbo O ,
Verma M ,
Liu J ,
Stanfield RL ,
Zhu X ,
Turner HL,
Sok D,
Huang PS ,
Burton DR ,
Ward AB ,
Wilson IA ,
Jardine JG
(2023) PNAS , 120 , e2216612120 - e2216612120
Grant Support:
- Bill & Melinda Gates Foundation: OPP1170236 (United States)
- Bill & Melinda Gates Foundation: INV-004923 (United States)