EMD-27627

Single-particle
2.96 Å
EMD-27627
3D View Gallery
Deposition: 14/07/2022
Map released: 19/07/2023
Last modified: 04/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-27627

Archive Files (Depositor)

Primary 3D volume (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8dp0 summary report (pdf.gz) Map-8dp0 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

Structure of p110 gamma bound to the Ras inhibitory nanobody NB7

EMD-27627

Single-particle
2.96 Å
EMD-27627
3D View Gallery
Deposition: 14/07/2022
Map released: 19/07/2023
Last modified: 04/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Lama glama
Sample: Complex of p110 gamma with NB7
Fitted models: 8dp0

Deposition Authors: Burke JE , Nam SE, Rathinaswamy MK, Yip CK , Nam SE
Allosteric activation or inhibition of PI3K gamma mediated through conformational changes in the p110 gamma helical domain.
Harris NJ, Jenkins ML , Nam SE, Rathinaswamy MK, Parson MAH , Ranga-Prasad H, Dalwadi U, Moeller BE, Sheeky E , Hansen SD , Yip CK , Burke JE
(2023) eLife , 12
PUBMED: 37417733
DOI: doi:10.7554/eLife.88058
ISSN: 2050-084X