EMD-27581

Single-particle
3.03 Å
EMD-27581
3D View Gallery
Deposition: 12/07/2022
Map released: 24/05/2023
Last modified: 06/09/2023
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-27581

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8dnv summary report (pdf.gz) Map-8dnv FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of the human Sec61 complex in a partially-open apo state (Class 1)

EMD-27581

Single-particle
3.03 Å
EMD-27581
3D View Gallery
Deposition: 12/07/2022
Map released: 24/05/2023
Last modified: 06/09/2023
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: A human-yeast chimeric Sec complex
Fitted models: 8dnv

Deposition Authors: Park E , Itskanov S
A common mechanism of Sec61 translocon inhibition by small molecules.
Itskanov S , Wang L , Junne T, Sherriff R , Xiao L, Blanchard N , Shi WQ , Forsyth C, Hoepfner D , Spiess M , Park E
(2023) Nat Chem Biol , 19 , 1063 - 1071
PUBMED: 37169959
DOI: doi:10.1038/s41589-023-01337-y
ISSN: 1552-4469
Grant Support: