Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-27327
PI 3-kinase alpha with nanobody 3-126
EMD-27327
Single-particle2.41 Å
Deposition: 17/06/2022Map released: 21/09/2022
Last modified: 12/06/2024
Sample Organism:
Homo sapiens
Sample: Human PI 3-kinase alpha complex composed of p110alpha and p85alpha with nanobody 3-126 bound
Fitted models: 8dcp
Deposition Authors: Hart JR
,
Liu X,
Pan C,
Liang A,
Ueno L ,
Xu Y,
Quezada A,
Zou X ,
Yang S,
Zhou Q ,
Schoonooghe S,
Hassanzadeh-Ghassabeh G,
Xia T,
Shui W,
Yang D ,
Vogt PK ,
Wang M-W
Sample: Human PI 3-kinase alpha complex composed of p110alpha and p85alpha with nanobody 3-126 bound
Fitted models: 8dcp
Deposition Authors: Hart JR
,
Liu X,
Pan C,
Liang A,
Ueno L ,
Xu Y,
Quezada A,
Zou X ,
Yang S,
Zhou Q ,
Schoonooghe S,
Hassanzadeh-Ghassabeh G,
Xia T,
Shui W,
Yang D ,
Vogt PK ,
Wang M-W
Nanobodies and chemical cross-links advance the structural and functional analysis of PI3K alpha.
Hart JR ,
Liu X,
Pan C,
Liang A,
Ueno L ,
Xu Y,
Quezada A,
Zou X ,
Yang S,
Zhou Q ,
Schoonooghe S,
Hassanzadeh-Ghassabeh G,
Xia T,
Shui W,
Yang D ,
Vogt PK ,
Wang MW
(2022) PNAS , 119 , e2210769119 - e2210769119
,
Liu X,
Pan C,
Liang A,
Ueno L ,
Xu Y,
Quezada A,
Zou X ,
Yang S,
Zhou Q ,
Schoonooghe S,
Hassanzadeh-Ghassabeh G,
Xia T,
Shui W,
Yang D ,
Vogt PK ,
Wang MW
(2022) PNAS , 119 , e2210769119 - e2210769119
Grant Support:
- National Institutes of Health/National Cancer Institute (NIH/NCI): R35 CA197582 (United States)
- National Institutes of Health/National Cancer Institute (NIH/NCI): R50 CA243899 (United States)
- National Natural Science Foundation of China (NSFC): 81872915 (China)
- National Natural Science Foundation of China (NSFC): 82073904 (China)
- National Natural Science Foundation of China (NSFC): 82121005 (China)
- National Natural Science Foundation of China (NSFC): 81973373 (China)
- National Natural Science Foundation of China (NSFC): 31971362 (China)
- National Natural Science Foundation of China (NSFC): 32171439 (China)
- National Natural Science Foundation of China (NSFC): 21704064 (China)
- Other government: 2018ZX09735 001
- Other government: 2018ZX09711002 002 005
- Other government: 2021ZD0203400
- Other government: 2018YFA0507000
- Other private: NNCAS 2017 1 CC
- Hainan Provincial Major Science and Technology Project: ZDKJ2021028 (China)