EMD-27240

Single-particle
3.1 Å
EMD-27240
3D View Gallery
Deposition: 07/06/2022
Map released: 20/07/2022
Last modified: 14/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-27240

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8d7z summary report (pdf.gz) Map-8d7z FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cereblon-DDB1 bound to CC-92480 and Ikaros ZF1-2-3

EMD-27240

Single-particle
3.1 Å
EMD-27240
3D View Gallery
Deposition: 07/06/2022
Map released: 20/07/2022
Last modified: 14/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Cereblon-DDB1 bound to CC-92480 and Ikaros
Fitted models: 8d7z

Deposition Authors: Watson ER , Lander GC
Molecular glue CELMoD compounds are regulators of cereblon conformation.
Watson ER , Novick S , Matyskiela ME, Chamberlain PP, H de la Pena A, Zhu J , Tran E, Griffin PR , Wertz IE, Lander GC
(2022) Science , 378 , 549 - 553
PUBMED: 36378961
DOI: doi:10.1126/science.add7574
ISSN: 1095-9203
ASTM: SCIEAS
Grant Support: