EMD-27237

Single-particle
3.4 Å
EMD-27237
3D View Gallery
Deposition: 07/06/2022
Map released: 20/07/2022
Last modified: 04/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-27237
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8d7x summary report (pdf.gz) Map and 8d7x FULL report (pdf.gz)
EMICSS annotations (xml)

Cereblon~DDB1 in the Apo form with DDB1 in the hinged conformation

EMD-27237

Single-particle
3.4 Å
EMD-27237
3D View Gallery
Deposition: 07/06/2022
Map released: 20/07/2022
Last modified: 04/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Cereblon~DDB1 in the Apo form with DDB1 in the hinged conformation
Fitted models: 8d7x

Deposition Authors: Watson ER , Lander GC
Molecular glue CELMoD compounds are regulators of cereblon conformation.
Watson ER , Novick S , Matyskiela ME, Chamberlain PP, H de la Pena A, Zhu J , Tran E, Griffin PR , Wertz IE, Lander GC
(2022) Science , 378 , 549 - 553
PUBMED: 36378961
DOI: doi:10.1126/science.add7574
ISSN: 1095-9203
ASTM: SCIEAS
Grant Support: