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EMD-27139
Cryo-EM structure of the VRC321 clinical trial, vaccine-elicited, human antibody 1B06 in complex with a stabilized NC99 HA trimer
EMD-27139
Single-particle3.96 Å
Deposition: 27/05/2022Map released: 12/04/2023
Last modified: 06/11/2024
Sample Organism:
Influenza A virus,
Homo sapiens
Sample: Cryo-EM structure of the VRC321 clinical trial, vaccine-elicited, human antibody 1B06 in complex with a stabilized NC99 HA trimer
Fitted models: 8d21
Deposition Authors: Gorman J
,
Kwong PD
Sample: Cryo-EM structure of the VRC321 clinical trial, vaccine-elicited, human antibody 1B06 in complex with a stabilized NC99 HA trimer
Fitted models: 8d21
Deposition Authors: Gorman J
,
Kwong PD
An influenza H1 hemagglutinin stem-only immunogen elicits a broadly cross-reactive B cell response in humans.
Andrews SF ,
Cominsky LY ,
Shimberg GD ,
Gillespie RA ,
Gorman J ,
Raab JE ,
Brand J ,
Creanga A ,
Gajjala SR,
Narpala S,
Cheung CSF,
Harris DR ,
Zhou T ,
Gordon I,
Holman L ,
Mendoza F,
Houser KV ,
Chen GL,
Mascola JR,
Graham BS ,
Kwong PD ,
Widge A,
Dropulic LK ,
Ledgerwood JE,
Kanekiyo M ,
McDermott AB
(2023) Sci Transl Med , 15 , eade4976 - eade4976
,
Cominsky LY ,
Shimberg GD ,
Gillespie RA ,
Gorman J ,
Raab JE ,
Brand J ,
Creanga A ,
Gajjala SR,
Narpala S,
Cheung CSF,
Harris DR ,
Zhou T ,
Gordon I,
Holman L ,
Mendoza F,
Houser KV ,
Chen GL,
Mascola JR,
Graham BS ,
Kwong PD ,
Widge A,
Dropulic LK ,
Ledgerwood JE,
Kanekiyo M ,
McDermott AB
(2023) Sci Transl Med , 15 , eade4976 - eade4976
Grant Support:
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM103310 (United States)
- Other private: Simons Foundation (SF349247) (United States)