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EMD-27103
Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer with LMHS mutations in complex with Temsavir, 8ANC195, and 10-1074
EMD-27103
Single-particle3.14 Å
Deposition: 25/05/2022Map released: 31/05/2023
Last modified: 16/10/2024
Sample Organism:
Homo sapiens,
Human immunodeficiency virus 1,
Severe acute respiratory syndrome coronavirus 2
Sample: Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer with LMHS mutations in complex with Temsavir, 8ANC195, and 10-1074
Fitted models: 8czz
Deposition Authors: Chen Y
,
Pozharski E,
Tolbert W,
Pazgier M
Sample: Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer with LMHS mutations in complex with Temsavir, 8ANC195, and 10-1074
Fitted models: 8czz
Deposition Authors: Chen Y
,
Pozharski E,
Tolbert W,
Pazgier M
Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir.
Prevost J ,
Chen Y ,
Zhou F,
Tolbert WD ,
Gasser R ,
Medjahed H,
Nayrac M ,
Nguyen DN,
Gottumukkala S,
Hessell AJ ,
Rao VB ,
Pozharski E,
Huang RK,
Matthies D ,
Finzi A,
Pazgier M
(2023) Nat Commun , 14 , 6710 - 6710
,
Chen Y ,
Zhou F,
Tolbert WD ,
Gasser R ,
Medjahed H,
Nayrac M ,
Nguyen DN,
Gottumukkala S,
Hessell AJ ,
Rao VB ,
Pozharski E,
Huang RK,
Matthies D ,
Finzi A,
Pazgier M
(2023) Nat Commun , 14 , 6710 - 6710
Grant Support:
- Other government: Start-up funds (United States)