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EMD-27078

Single-particle
3.14 Å
EMD-27078
3D View Gallery
Deposition: 23/05/2022
Map released: 12/04/2023
Last modified: 12/06/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-27078
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8cyi summary report (pdf.gz) Map and 8cyi FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structures and computational analysis for enhanced potency in MTA-synergic inhibition of human protein arginine methyltransferase 5

EMD-27078

Single-particle
3.14 Å
EMD-27078
3D View Gallery
Deposition: 23/05/2022
Map released: 12/04/2023
Last modified: 12/06/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Complex of PRMT5 and MEP50 in the presence of MTA and a novel inhibitor (11-2F)
Fitted models: 8cyi

Deposition Authors: Yadav GP , Wei Z, Xiaozhi Y, Chenglong L, Jiang Q
Cryo-EM structure-based selection of computed ligand poses enables design of MTA-synergic PRMT5 inhibitors of better potency.
Zhou W , Yadav GP , Yang X, Qin F, Li C , Jiang QX
(2022) Commun Biol , 5 , 1054 - 1054
PUBMED: 36192627
DOI: doi:10.1038/s42003-022-03991-9
ISSN: 2399-3642