EMD-27025

Single-particle
2.9 Å
EMD-27025
3D View Gallery
Deposition: 19/05/2022
Map released: 08/03/2023
Last modified: 28/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-27025

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8cwl summary report (pdf.gz) Map-8cwl FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

CRYO-EM STRUCTURE OF HUMAN 15-PGDH IN COMPLEX WITH SMALL MOLECULE SW222746

EMD-27025

Single-particle
2.9 Å
EMD-27025
3D View Gallery
Deposition: 19/05/2022
Map released: 08/03/2023
Last modified: 28/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: HUMAN 15-PGDH IN COMPLEX WITH INHIBITOR
Fitted models: 8cwl

Deposition Authors: Huang W , Taylor DJ
Small molecule inhibitors of 15-PGDH exploit a physiologic induced-fit closing system.
Huang W , Li H, Kiselar J, Fink SP , Regmi S , Day A, Yuan Y, Chance M, Ready JM, Markowitz SD , Taylor DJ
(2023) Nat Commun , 14 , 784 - 784
PUBMED: 36774348
DOI: doi:10.1038/s41467-023-36463-7
ISSN: 2041-1723