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EMD-26665
Tau Paired Helical Filament from Alzheimer's Disease incubated with EGCG for 3 hours
EMD-26665
Helical reconstruction3.8 Å
Deposition: 15/04/2022Map released: 28/09/2022
Last modified: 12/06/2024
Sample Organism:
Homo sapiens
Sample: Tau Paired Helical Filament from Alzheimer's Disease incubated with EGCG for 3 hours
Fitted models: 7upg
Deposition Authors: Seidler PM, Murray KA, Boyer DR
,
Ge P ,
Sawaya MR ,
Eisenberg DS
Sample: Tau Paired Helical Filament from Alzheimer's Disease incubated with EGCG for 3 hours
Fitted models: 7upg
Deposition Authors: Seidler PM, Murray KA, Boyer DR
,
Ge P ,
Sawaya MR ,
Eisenberg DS
Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro.
Seidler PM,
Murray KA,
Boyer DR ,
Ge P ,
Sawaya MR ,
Hu CJ ,
Cheng X,
Abskharon R,
Pan H ,
DeTure MA,
Williams CK,
Dickson DW ,
Vinters HV,
Eisenberg DS
(2022) Nat Commun , 13 , 5451 - 5451
,
Ge P ,
Sawaya MR ,
Hu CJ ,
Cheng X,
Abskharon R,
Pan H ,
DeTure MA,
Williams CK,
Dickson DW ,
Vinters HV,
Eisenberg DS
(2022) Nat Commun , 13 , 5451 - 5451
Grant Support:
- National Institutes of Health/National Institute on Aging (NIH/NIA): 1R01 AG029430 (United States)
- National Institutes of Health/National Institute on Aging (NIH/NIA): AG061847 (United States)
- National Institutes of Health/National Institute on Aging (NIH/NIA): RF1 AG054022 (United States)
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): 1F32 NS095661 (United States)