Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-26584

Single-particle
3.03 Å
EMD-26584
3D View Gallery
Deposition: 01/04/2022
Map released: 04/10/2023
Last modified: 24/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-26584
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7ukm summary report (pdf.gz) Map and 7ukm FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of Antibody 12-19 in complex with prefusion SARS-CoV-2 Spike glycoprotein

EMD-26584

Single-particle
3.03 Å
EMD-26584
3D View Gallery
Deposition: 01/04/2022
Map released: 04/10/2023
Last modified: 24/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Severe acute respiratory syndrome coronavirus 2, Homo sapiens
Sample: Antibody 12-19 in complex with prefusion SARS-CoV-2 Spike glycoprotein
Fitted models: 7ukm

Deposition Authors: Casner RG, Shapiro L
Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking.
Liu L , Casner RG, Guo Y , Wang Q, Iketani S , Chan JF, Yu J, Dadonaite B, Nair MS, Mohri H, Reddem ER, Yuan S , Poon VK, Chan CC, Yuen KY, Sheng Z, Huang Y, Bloom JD, Shapiro L, Ho DD
(2023) Immunity , 56 , 2442 - 2455.e8
PUBMED: 37776849
DOI: doi:10.1016/j.immuni.2023.09.003
ISSN: 1074-7613
ASTM: IUNIEH
Grant Support: