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EMD-26443
Structure of the DU422 SOSIP.664 trimer in complex with neutralizing antibody Fab fragments 10-1074 and BG24
EMD-26443
Single-particle3.5 Å
Deposition: 16/03/2022Map released: 17/08/2022
Last modified: 20/11/2024
Sample Organism:
Homo sapiens,
Human immunodeficiency virus 1
Sample: Complex of DU422 SOSIP trimer bound to 10-1074 and BG24 Fab fragments
Fitted models: 7ucg
Deposition Authors: Barnes CO
,
Bjorkman PJ
Sample: Complex of DU422 SOSIP trimer bound to 10-1074 and BG24 Fab fragments
Fitted models: 7ucg
Deposition Authors: Barnes CO
,
Bjorkman PJ
A naturally arising broad and potent CD4-binding site antibody with low somatic mutation.
Barnes CO ,
Schoofs T ,
Gnanapragasam PNP,
Golijanin J,
Huey-Tubman KE,
Gruell H ,
Schommers P ,
Suh-Toma N,
Lee YE ,
Cetrulo Lorenzi JC,
Piechocka-Trocha A ,
Scheid JF,
West Jr AP ,
Walker BD ,
Seaman MS ,
Klein F ,
Nussenzweig MC ,
Bjorkman PJ
(2022) Sci Adv , 8 , eabp8155 - eabp8155
,
Schoofs T ,
Gnanapragasam PNP,
Golijanin J,
Huey-Tubman KE,
Gruell H ,
Schommers P ,
Suh-Toma N,
Lee YE ,
Cetrulo Lorenzi JC,
Piechocka-Trocha A ,
Scheid JF,
West Jr AP ,
Walker BD ,
Seaman MS ,
Klein F ,
Nussenzweig MC ,
Bjorkman PJ
(2022) Sci Adv , 8 , eabp8155 - eabp8155
Grant Support:
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): P01 AI100148 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): P50 AI150464 (United States)
- Bill & Melinda Gates Foundation: OPP1124068 (United States)