Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-26414

Composite map
Single-particle
2.93 Å
EMD-26414
3D View Gallery
Deposition: 11/03/2022
Map released: 03/08/2022
Last modified: 20/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-26414
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7ua4 summary report (pdf.gz) Map and 7ua4 FULL report (pdf.gz)
EMICSS annotations (xml)

Structure of PKA phosphorylated human RyR2-R2474S in the open state in the presence of Calmodulin

EMD-26414

Composite map
Single-particle
2.93 Å
EMD-26414
3D View Gallery
Deposition: 11/03/2022
Map released: 03/08/2022
Last modified: 20/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Complex of RyR2-R2474S, Calstabin-2, and Calmodulin
Fitted models: 7ua4

Deposition Authors: Miotto MC , Marks AR
Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment.
Miotto MC , Weninger G , Dridi H , Yuan Q, Liu Y , Wronska A , Melville Z , Sittenfeld L , Reiken S , Marks AR
(2022) Sci Adv , 8 , eabo1272 - eabo1272
PUBMED: 35857850
DOI: doi:10.1126/sciadv.abo1272
ISSN: 2375-2548