Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-26279
TMEM106B(120-254) protofilament from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type A (all cases combined).
EMD-26279
Helical reconstruction2.7 Å
Deposition: 19/02/2022Map released: 23/03/2022
Last modified: 04/06/2025
Sample Organism:
Homo sapiens
Sample: TMEM106B(120-254) singlet amyloid fibril from dementia with Lewy bodies (DLB).
Fitted models: 7u16
Deposition Authors: Fitzpatrick AWP
,
Stowell MHB
Sample: TMEM106B(120-254) singlet amyloid fibril from dementia with Lewy bodies (DLB).
Fitted models: 7u16
Deposition Authors: Fitzpatrick AWP
,
Stowell MHB
Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases.
Chang A ,
Xiang X ,
Wang J,
Lee C,
Arakhamia T,
Simjanoska M,
Wang C,
Carlomagno Y,
Zhang G,
Dhingra S,
Thierry M,
Perneel J ,
Heeman B ,
Forgrave LM,
DeTure M,
DeMarco ML ,
Cook CN,
Rademakers R,
Dickson DW,
Petrucelli L,
Stowell MHB ,
Mackenzie IRA,
Fitzpatrick AWP
(2022) Cell , 185 , 1346 - 1355.e15
,
Xiang X ,
Wang J,
Lee C,
Arakhamia T,
Simjanoska M,
Wang C,
Carlomagno Y,
Zhang G,
Dhingra S,
Thierry M,
Perneel J ,
Heeman B ,
Forgrave LM,
DeTure M,
DeMarco ML ,
Cook CN,
Rademakers R,
Dickson DW,
Petrucelli L,
Stowell MHB ,
Mackenzie IRA,
Fitzpatrick AWP
(2022) Cell , 185 , 1346 - 1355.e15
Grant Support: