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EMD-26275
TMEM106B(120-254) singlet amyloid fibril from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type A (case 2)
EMD-26275
Helical reconstruction3.5 Å
Deposition: 19/02/2022Map released: 23/03/2022
Last modified: 21/05/2025
Sample Organism:
Homo sapiens
Sample: TMEM106B(120-254) singlet amyloid fibril from dementia with Lewy bodies (DLB)
Fitted models: 7u12
Deposition Authors: Fitzpatrick AWP
,
Stowell MHB
Sample: TMEM106B(120-254) singlet amyloid fibril from dementia with Lewy bodies (DLB)
Fitted models: 7u12
Deposition Authors: Fitzpatrick AWP
,
Stowell MHB
Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases.
Chang A ,
Xiang X ,
Wang J,
Lee C,
Arakhamia T,
Simjanoska M,
Wang C,
Carlomagno Y,
Zhang G,
Dhingra S,
Thierry M,
Perneel J ,
Heeman B ,
Forgrave LM,
DeTure M,
DeMarco ML ,
Cook CN,
Rademakers R,
Dickson DW,
Petrucelli L,
Stowell MHB ,
Mackenzie IRA,
Fitzpatrick AWP
(2022) Cell , 185 , 1346 - 1355.e15
,
Xiang X ,
Wang J,
Lee C,
Arakhamia T,
Simjanoska M,
Wang C,
Carlomagno Y,
Zhang G,
Dhingra S,
Thierry M,
Perneel J ,
Heeman B ,
Forgrave LM,
DeTure M,
DeMarco ML ,
Cook CN,
Rademakers R,
Dickson DW,
Petrucelli L,
Stowell MHB ,
Mackenzie IRA,
Fitzpatrick AWP
(2022) Cell , 185 , 1346 - 1355.e15
Grant Support: