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EMD-26103
Cryo-EM structure of corticotropin releasing factor receptor 2 bound to Urocortin 1 and coupled with heterotrimeric G11 protein
EMD-26103
Single-particle3.7 Å
Deposition: 31/01/2022Map released: 09/11/2022
Last modified: 04/06/2025
Sample Organism:
Homo sapiens,
Rattus norvegicus,
synthetic construct
Sample: Corticotropin releasing factor receptor 2 (CRF2R) bound to Urocortin 1 (UCN1) and coupled with G11 proteins
Fitted models: 7try
Deposition Authors: Zhao L-H, Lin J
,
Mao C
,
Zhou XE,
Ji S,
Shen D,
Xiao P
,
Melcher K
,
Zhang Y
,
Yu X
,
Xu HE
Sample: Corticotropin releasing factor receptor 2 (CRF2R) bound to Urocortin 1 (UCN1) and coupled with G11 proteins
Fitted models: 7try
Deposition Authors: Zhao L-H, Lin J
,
Mao C
,
Zhou XE,
Ji S,
Shen D,
Xiao P
,
Melcher K
,
Zhang Y
,
Yu X
,
Xu HE
Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor.
Zhao LH,
Lin J
,
Ji SY,
Zhou XE,
Mao C
,
Shen DD
,
He X
,
Xiao P
,
Sun J,
Melcher K
,
Zhang Y
,
Yu X
,
Xu HE
(2022) Nat Commun , 13 , 6670 - 6670
,
Ji SY,
Zhou XE,
Mao C
,
Shen DD
,
He X
,
Xiao P
,
Sun J,
Melcher K
,
Zhang Y
,
Yu X
,
Xu HE
(2022) Nat Commun , 13 , 6670 - 6670
Grant Support:
- National Natural Science Foundation of China (NSFC): 32071203 (China)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM127710 (United States)
- National Natural Science Foundation of China (NSFC): 31971195 (China)
- National Natural Science Foundation of China (NSFC): 81922071 (China)
- National Natural Science Foundation of China (NSFC): 32100959 (China)
