Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-26103

Single-particle
3.7 Å
EMD-26103 Deposition: 31/01/2022
Map released: 09/11/2022
Last modified: 04/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-26103

Cryo-EM structure of corticotropin releasing factor receptor 2 bound to Urocortin 1 and coupled with heterotrimeric G11 protein

EMD-26103

Single-particle
3.7 Å
EMD-26103 Deposition: 31/01/2022
Map released: 09/11/2022
Last modified: 04/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Rattus norvegicus, synthetic construct
Sample: Corticotropin releasing factor receptor 2 (CRF2R) bound to Urocortin 1 (UCN1) and coupled with G11 proteins
Fitted models: 7try

Deposition Authors: Zhao L-H, Lin J , Mao C , Zhou XE, Ji S, Shen D, Xiao P , Melcher K , Zhang Y , Yu X , Xu HE
Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor.
Zhao LH, Lin J , Ji SY, Zhou XE, Mao C , Shen DD , He X , Xiao P , Sun J, Melcher K , Zhang Y , Yu X , Xu HE
(2022) Nat Commun , 13 , 6670 - 6670
PUBMED: 36335102
DOI: doi:10.1038/s41467-022-33851-3
ISSN: 2041-1723