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EMD-26054
Single-Particle Cryo-EM Structure of the WaaL O-antigen ligase in its ligand bound state
EMD-26054
Single-particle3.23 Å
Deposition: 25/01/2022Map released: 06/04/2022
Last modified: 13/11/2024
Sample Organism:
Homo sapiens,
Cupriavidus metallidurans
Sample: Ligand Bound CmWaaL with Fab fragment bound
Fitted models: 7tpg
Deposition Authors: Ashraf KU
,
Nygaard R
Sample: Ligand Bound CmWaaL with Fab fragment bound
Fitted models: 7tpg
Deposition Authors: Ashraf KU
,
Nygaard R
Structural basis of lipopolysaccharide maturation by the O-antigen ligase.
Ashraf KU ,
Nygaard R ,
Vickery ON,
Erramilli SK ,
Herrera CM,
McConville TH,
Petrou VI ,
Giacometti SI ,
Dufrisne MB,
Nosol K ,
Zinkle AP,
Graham CLB ,
Loukeris M ,
Kloss B ,
Skorupinska-Tudek K,
Swiezewska E ,
Roper DI ,
Clarke OB ,
Uhlemann AC ,
Kossiakoff AA,
Trent MS ,
Stansfeld PJ ,
Mancia F
(2022) Nature , 604 , 371 - 376
,
Nygaard R ,
Vickery ON,
Erramilli SK ,
Herrera CM,
McConville TH,
Petrou VI ,
Giacometti SI ,
Dufrisne MB,
Nosol K ,
Zinkle AP,
Graham CLB ,
Loukeris M ,
Kloss B ,
Skorupinska-Tudek K,
Swiezewska E ,
Roper DI ,
Clarke OB ,
Uhlemann AC ,
Kossiakoff AA,
Trent MS ,
Stansfeld PJ ,
Mancia F
(2022) Nature , 604 , 371 - 376
Grant Support:
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM132120 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): AI150098 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): AI138576 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): AI129940 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM117372 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM116799 (United States)
- National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK): DK104309 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): AI100852 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): AI146284 (United States)
- Wellcome Trust: 208361/Z/17/Z (United Kingdom)
- Medical Research Council (MRC, United Kingdom): MR/S009213/1 (United Kingdom)
- Biotechnology and Biological Sciences Research Council (BBSRC): BB/P01948X/1 (United Kingdom)
- Biotechnology and Biological Sciences Research Council (BBSRC): BB/R002517/1 (United Kingdom)
- Biotechnology and Biological Sciences Research Council (BBSRC): BB/S003339/1 (United Kingdom)
- Engineering and Physical Sciences Research Council: EP/R029407/1 (United Kingdom)
- Engineering and Physical Sciences Research Council: EP/P020232/1 (United Kingdom)
- Biotechnology and Biological Sciences Research Council (BBSRC): BB/M01116X/1 (United Kingdom)
- Medical Research Council (MRC, United Kingdom): MR/N002679/1 (United Kingdom)