Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-26035

Single-particle
3.1 Å
EMD-26035
3D View Gallery
Deposition: 24/01/2022
Map released: 25/05/2022
Last modified: 21/02/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-26035
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7toq summary report (pdf.gz) Map and 7toq FULL report (pdf.gz)
EMICSS annotations (xml)

Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein poly-PR

EMD-26035

Single-particle
3.1 Å
EMD-26035
3D View Gallery
Deposition: 24/01/2022
Map released: 25/05/2022
Last modified: 21/02/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Oryctolagus cuniculus, Saccharomyces cerevisiae, Homo sapiens, Escherichia coli K-12
Sample: Mamalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein PR20
Fitted models: 7toq

Deposition Authors: Loveland AB , Svidritskiy E, Susorov D , Lee S, Park A, Zvornicanin S, Demo G , Gao FB , Korostelev AA
Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.
Loveland AB , Svidritskiy E, Susorov D , Lee S, Park A, Zvornicanin S, Demo G , Gao FB , Korostelev AA
(2022) Nat Commun , 13 , 2776 - 2776
PUBMED: 35589706
DOI: doi:10.1038/s41467-022-30418-0
ISSN: 2041-1723