Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-25906

Single-particle
5.2 Å
EMD-25906
3D View Gallery
Deposition: 12/01/2022
Map released: 28/12/2022
Last modified: 05/06/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-25906
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7thy summary report (pdf.gz) Map and 7thy FULL report (pdf.gz)
EMICSS annotations (xml)

Structure of Leucine Rich Repeat Kinase 2's ROC domain interacting with the microtubule facing the minus end

EMD-25906

Single-particle
5.2 Å
EMD-25906
3D View Gallery
Deposition: 12/01/2022
Map released: 28/12/2022
Last modified: 05/06/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: LRRK2RCKW filament bound to a 11-pf microtubule with MLi-2 present
Fitted models: 7thy

Deposition Authors: Matyszewski M , Leschziner AE
Structural basis for Parkinson's disease-linked LRRK2's binding to microtubules.
Snead DM, Matyszewski M , Dickey AM , Lin YX, Leschziner AE , Reck-Peterson SL
(2022) Nat Struct Mol Biol , 29 , 1196 - 1207
PUBMED: 36510024
DOI: doi:10.1038/s41594-022-00863-y
ISSN: 1545-9985