EMD-25762

Single-particle
3.1 Å
EMD-25762
3D View Gallery
Deposition: 19/12/2021
Map released: 10/08/2022
Last modified: 09/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-25762

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-7t9m summary report (pdf.gz) Map-7t9m FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Human Thyrotropin receptor bound by CS-17 Inverse Agonist Fab/Org 274179-0 Antagonist

EMD-25762

Single-particle
3.1 Å
EMD-25762
3D View Gallery
Deposition: 19/12/2021
Map released: 10/08/2022
Last modified: 09/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: Human Thyrotropin receptor in complex with the murine inverse agonist Fab fragment CS-17
Fitted models: 7t9m

Deposition Authors: Faust B , Cheng Y , Manglik A
Autoantibody mimicry of hormone action at the thyrotropin receptor.
Faust B , Billesbolle CB , Suomivuori CM , Singh I, Zhang K, Hoppe N, Pinto AFM , Diedrich JK, Muftuoglu Y, Szkudlinski MW , Saghatelian A, Dror RO , Cheng Y , Manglik A
(2022) Nature , 609 , 846 - 853
PUBMED: 35940205
DOI: doi:10.1038/s41586-022-05159-1
ISSN: 1476-4687
ASTM: NATUAS