EMD-25613

Single-particle
3.2 Å
EMD-25613
3D View Gallery
Deposition: 04/12/2021
Map released: 07/12/2022
Last modified: 14/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-25613
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7t2h summary report (pdf.gz) Map and 7t2h FULL report (pdf.gz)
EMICSS annotations (xml)

CryoEM structure of mu-opioid receptor - Gi protein complex bound to lofentanil (LFT)

EMD-25613

Single-particle
3.2 Å
EMD-25613
3D View Gallery
Deposition: 04/12/2021
Map released: 07/12/2022
Last modified: 14/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus, Homo sapiens
Sample: mu-opioid receptor - Gi protein complex bound to lofentanil (LFT)
Fitted models: 7t2h

Deposition Authors: Seven AB, Qu Q , Huang W, Robertson MJ , Kobilka BK , Skiniotis G
Insights into distinct signaling profiles of the mu OR activated by diverse agonists.
Qu Q , Huang W, Aydin D , Paggi JM, Seven AB, Wang H, Chakraborty S, Che T , DiBerto JF, Robertson MJ , Inoue A , Suomivuori CM , Roth BL , Majumdar S , Dror RO , Kobilka BK , Skiniotis G
(2022) Nat Chem Biol
PUBMED: 36411392
DOI: doi:10.1038/s41589-022-01208-y
ISSN: 1552-4469