Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-25612

Single-particle
2.5 Å
EMD-25612
3D View Gallery
Deposition: 04/12/2021
Map released: 07/12/2022
Last modified: 28/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-25612
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7t2g summary report (pdf.gz) Map and 7t2g FULL report (pdf.gz)
EMICSS annotations (xml)

CryoEM structure of mu-opioid receptor - Gi protein complex bound to mitragynine pseudoindoxyl (MP)

EMD-25612

Single-particle
2.5 Å
EMD-25612
3D View Gallery
Deposition: 04/12/2021
Map released: 07/12/2022
Last modified: 28/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: mu-opioid receptor / Gi protein complex bound to mitragynine pseudoindoxyl (MP).
Fitted models: 7t2g

Deposition Authors: Seven AB, Qu Q , Robertson MJ , Wang H, Kobilka BK
Insights into distinct signaling profiles of the mu OR activated by diverse agonists.
Qu Q , Huang W, Aydin D , Paggi JM, Seven AB, Wang H, Chakraborty S, Che T , DiBerto JF, Robertson MJ , Inoue A , Suomivuori CM , Roth BL , Majumdar S , Dror RO , Kobilka BK , Skiniotis G
(2022) Nat Chem Biol
PUBMED: 36411392
DOI: doi:10.1038/s41589-022-01208-y
ISSN: 1552-4469