EMD-25523

Single-particle
3.3 Å
EMD-25523
3D View Gallery
Deposition: 24/11/2021
Map released: 22/12/2021
Last modified: 16/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-25523

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-7sye summary report (pdf.gz) Map-7sye FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

Cryo-EM structure of the extracellular module of the full-length EGFR bound to EGF. "tips-separated" conformation

EMD-25523

Single-particle
3.3 Å
EMD-25523
3D View Gallery
Deposition: 24/11/2021
Map released: 22/12/2021
Last modified: 16/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: full-length human EGFR:EGF complex
Fitted models: 7sye

Deposition Authors: Huang Y , Ognjenovic J
A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor.
Huang Y , Ognjenovic J, Karandur D , Miller K , Merk A, Subramaniam S , Kuriyan J
(2021) eLife , 10
PUBMED: 34846302
DOI: doi:10.7554/eLife.73218
ISSN: 2050-084X
Grant Support: