Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-25447

Single-particle
2.7 Å
EMD-25447
3D View Gallery
Deposition: 18/11/2021
Map released: 12/01/2022
Last modified: 04/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-25447
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7svd summary report (pdf.gz) Map and 7svd FULL report (pdf.gz)
EMICSS annotations (xml)

The complex of phosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) with ATP/Mg and Lumacaftor (VX-809)

EMD-25447

Single-particle
2.7 Å
EMD-25447
3D View Gallery
Deposition: 18/11/2021
Map released: 12/01/2022
Last modified: 04/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: The complex of phosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) with ATP/Mg and Lumacaftor (VX-809)
Fitted models: 7svd

Deposition Authors: Fiedorczuk K, Chen J
Mechanism of CFTR correction by type I folding correctors.
Fiedorczuk K, Chen J
(2022) Cell , 185 , 158 - 168.e11
PUBMED: 34995514
DOI: doi:10.1016/j.cell.2021.12.009
ISSN: 1097-4172
Grant Support: