EMD-25431

Single-particle
4.0 Å
EMD-25431
3D View Gallery
Deposition: 14/11/2021
Map released: 30/03/2022
Last modified: 13/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-25431

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-7stk summary report (pdf.gz) Map-7stk FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

Full-length insulin receptor bound with unsaturated insulin WT (2 insulins bound) asymmetric conformation (Conformation 2)

EMD-25431

Single-particle
4.0 Å
EMD-25431
3D View Gallery
Deposition: 14/11/2021
Map released: 30/03/2022
Last modified: 13/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus, Homo sapiens
Sample: Full-length insulin receptor bound with unsaturated insulin WT (2 insulins bound) asymmetric conformation (Conformation 2)
Fitted models: 7stk

Deposition Authors: Bai XC, Choi E
Synergistic activation of the insulin receptor via two distinct sites.
Li J , Park J , Mayer JP, Webb KJ, Uchikawa E , Wu J , Liu S, Zhang X , Stowell MHB , Choi E , Bai XC
(2022) Nat Struct Mol Biol , 29 , 357 - 368
PUBMED: 35361965
DOI: doi:10.1038/s41594-022-00750-6
ISSN: 1545-9985