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EMD-25430

Single-particle
4.4 Å
EMD-25430
3D View Gallery
Deposition: 14/11/2021
Map released: 30/03/2022
Last modified: 06/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-25430
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7stj summary report (pdf.gz) Map and 7stj FULL report (pdf.gz)
EMICSS annotations (xml)

Full-length insulin receptor bound with unsaturated insulin WT (2 insulins bound) asymmetric conformation (Conformation 1)

EMD-25430

Single-particle
4.4 Å
EMD-25430
3D View Gallery
Deposition: 14/11/2021
Map released: 30/03/2022
Last modified: 06/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus, Homo sapiens
Sample: Full-length insulin receptor bound with unsaturated insulin WT (2 insulins bound) asymmetric conformation (Conformation 1)
Fitted models: 7stj

Deposition Authors: Bai XC, Choi E
Synergistic activation of the insulin receptor via two distinct sites.
Li J , Park J , Mayer JP, Webb KJ, Uchikawa E , Wu J , Liu S, Zhang X , Stowell MHB , Choi E , Bai XC
(2022) Nat Struct Mol Biol , 29 , 357 - 368
PUBMED: 35361965
DOI: doi:10.1038/s41594-022-00750-6
ISSN: 1545-9985