EMDB < EMD-25430

EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Research:

perform basic research in molecular biology

Services:

offer vital services to scientists in the member states

Training

scientists, students and visitors at all levels

Transfer

and development of technology

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

EMD-25430

Single-particle
4.4 Å

EMD-25430

3D View Gallery

Deposition: 14/11/2021
Map released: 30/03/2022
Last modified: 06/11/2024

Overview 3D View Sample Experiment Validation Volume Browser Additional data Links

Overview 3D View Sample Experiment Validation Volume Browser Additional data Links

EMD-25430

Download

Full-length insulin receptor bound with unsaturated insulin WT (2 insulins bound) asymmetric conformation (Conformation 1)

EMD-25430

Single-particle
4.4 Å
EMD-25430

EMD-25430

3D View Gallery

Deposition: 14/11/2021
Map released: 30/03/2022
Last modified: 06/11/2024

Overview 3D View Sample Experiment Validation Volume Browser Additional data Links

Sample Organism: Mus musculus, Homo sapiens
Sample: Full-length insulin receptor bound with unsaturated insulin WT (2 insulins bound) asymmetric conformation (Conformation 1)
Fitted models: 7stj

Deposition Authors: Bai XC , Choi E

Synergistic activation of the insulin receptor via two distinct sites.

Li J , Park J , Mayer JP, Webb KJ, Uchikawa E , Wu J , Liu S, Zhang X , Stowell MHB , Choi E , Bai XC
(2022) Nat Struct Mol Biol , 29 , 357 - 368

PUBMED: 35361965
DOI: doi:10.1038/s41594-022-00750-6
ISSN: 1545-9985

Field: