EMD-25389

Single-particle
3.17 Å
EMD-25389
3D View Gallery
Deposition: 05/11/2021
Map released: 25/05/2022
Last modified: 06/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-25389

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-7sqo summary report (pdf.gz) Map-7sqo FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

Structure of the orexin-2 receptor (OX2R) bound to TAK-925, Gi and scFv16

EMD-25389

Single-particle
3.17 Å
EMD-25389
3D View Gallery
Deposition: 05/11/2021
Map released: 25/05/2022
Last modified: 06/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Bos taurus, synthetic construct
Sample: Human OX2R in complex with Gai/Gb/Gg-scFv16.
Fitted models: 7sqo

Deposition Authors: McGrath AP, Kang Y
Molecular mechanism of the wake-promoting agent TAK-925.
Yin J, Kang Y, McGrath AP, Chapman K, Sjodt M, Kimura E, Okabe A, Koike T , Miyanohana Y, Shimizu Y, Rallabandi R , Lian P, Bai X , Flinspach M , De Brabander JK , Rosenbaum DM
(2022) Nat Commun , 13 , 2902 - 2902
PUBMED: 35614071
DOI: doi:10.1038/s41467-022-30601-3
ISSN: 2041-1723
Grant Support: